Immunodeficiency disorders (AIDS disease) have gone from being a death sentence to manageable chronic and curable diseases due to continuous increase of knowledge such that we now understand better what we are dealing with.
WHAT IS THE PROBLEM?
What are referred to as HIV are actually several. Two of them are microorganisms.
- The microorganism is actually SV40 or simian virus or a virus for monkeys.
- Then also, the microorganism (HIV) is actually a mycoplasma fermentans incognitus. These two microorganisms are made-made.
MODE OF TRANSMISSION:
One of these microorganisms is transmitted via injections as vaccines or drugs as by homosexuals while another is through vaginal sex and or body secretions.
THE PROBLEM WITH ANTIRETRTOVIRAL DRUGS:
If we have to go beyond the provisions of antiretrivral drugs, we must understand them, their strengths together with their limitations which are as follows:
- The current drugs and the immune system fail to detect the sleeping or "latent" HIV hiding in the body's cells.
- The current drugs cause acidosis as a side effect, a prerequisite condition for the development of cancers and organ failures. This is the reason cases of cancer and organ failure in AIDS patients on these drugs are high above the roof.
- These antiretroviral drugs do not eliminate chronic inflammation; instead they present acidosis, a pre condition for the development and acceleration of the same chronic inflammation.
Whilst these drugs are able to actively put HIV in remission to undetactable levels, they are not able to eradicate the virus. They are only able to reduce the viral load and keeping some of virus dormantly hidden in resevoirs. These resevoirs in which HIV virus hides include the brain, spleen, lymph and central nervous system. The virus remain dormant in these resevoirs simply becuase these medicines are not able to penetrate these resevoirs. These resevoirs are a very small number of immune system cells that have the virus intergrated into their genomes. These virus cells are completely undetectable by the immune system becuase the virus is dormant. This dormant virus is reactived once a patient abruptly stops taking medication.
GOING BEYOND ANTIRETROBIRAL DRUGS
During an SV40 or mycoplsama infection (SV40 cum HIV infection), two things happen simultaneously. There is a persistent activation of the immune system and chronic inflammation. This inflammation is characterized by the simultaneous destruction and tearing of tissue in the underlying organs.
This destruction of tissues is because chronic inflammation tends to produce reactive oxygen species and reactive nitrogen species, which cause oxidative damage and further lead to chronic diseases. Inflammation also recruits leukocytes that secrete inflammatory cytokines and angiogenic factors to the site of tissue insult.
These cytokines are normally required for proper wound healing and to stimulate epithelial cell proliferation; however, if uncontrolled these cytokines can lead to inflammatory disorders among them being immunodeficiency and autoimmune diseases.
The root cause to this persistent activation of the immune system and chronic inflammation is the constitutive activation of NF-kB, a nuclear factor transcription molecule in HIV infected myeloid cells, a situation caused by the continuous signal-induced degration of IkB gene responsible for regulating the NF-kB whenever an inflammation response is activated against stimuli.
Persistent activation of NK-kB occurs in human immunodeficiency virus infected monocytes, macrophages and microglia and enhances the expression of NF-kB response genes, including pro-inflammatory cytokines, cell adhesion molecules and chemokines resulting in chronic inflammation of affected tissues and organs.
Thus, blocking this pathway by eliminating this chronic inflammation becomes an important strategy in targeting long-lived HIV (SV40) infected myeloid cells.